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Cell proliferation and apoptosis inhibition: essential processes for recruitment of the full thermogenic capacity-of-brown-adipose-tissue
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Number of Authors: 32019 (English)In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, ISSN 1388-1981, E-ISSN 1879-2618, Vol. 1864, no 1, p. 51-58Article, review/survey (Refereed) Published
Abstract [en]

In mice living under normal animal house conditions, the brown adipocytes in classical brown adipose tissue depots are already essentially fully differentiated: UCP1 mRNA and UCP1 protein levels are practically saturated. This means that any further recruitment in response to cold exposure or any other browning agent - does not result in significant augmentation of these parameters. This may easily be construed to indicate that classical brown adipose tissue cannot be further recruited. However, this is far from the case: the capacity for further recruitment instead lies in the ability of the tissue to increase the number of brown-fat cells, a remarkable and highly controlled physiological recruitment process. We have compiled here the available data concerning the unique ability of norepinephrine to increase cell proliferation and inhibit apoptosis in brown adipocytes. Adrenergically stimulated cell proliferation is fully mediated via beta(1)-adrenoceptors and occurs through activation of stem cells in the tissue; intracellular mediation of the signal involves CAMP and protein kinase A activation, but activation of Erk1/2 is not part of the pathway. Apoptosis inhibition in brown adipocytes is induced by both beta- and alpha(1)-adrenergic receptors and here the intracellular pathway includes Erk1/2 activation. This unique ability of norepinephrine to increase cell number in an apparently mitogenically dormant tissue provides possibilities to augment the metabolic capacity of brown adipose tissue, also for therapeutic purposes.

Place, publisher, year, edition, pages
2019. Vol. 1864, no 1, p. 51-58
Keywords [en]
Brown adipose tissue, Cell proliferation, Apoptosis, Norepinephrine
National Category
Biochemistry and Molecular Biology Biophysics Cell Biology
Identifiers
URN: urn:nbn:se:su:diva-163517DOI: 10.1016/j.bbalip.2018.06.013ISI: 000452584200007PubMedID: 29908367OAI: oai:DiVA.org:su-163517DiVA, id: diva2:1276974
Available from: 2019-01-09 Created: 2019-01-09 Last updated: 2019-01-09Bibliographically approved

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