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Analytic approach to explore dynamical osteoporotic bone turnover
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab). Comsats University Islamabad, Pakistan.
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Number of Authors: 52019 (English)In: Advances in Difference Equations, ISSN 1687-1839, E-ISSN 1687-1847, article id 61Article in journal (Refereed) Published
Abstract [en]

The dynamics of the osteoporotic bone turnover is studied in this paper with the aid of stability analysis of the associated mathematical model. Osteoporosis, which is a common bone disorder, is studied in this papper in detail with an emphasis on the relative threshold values. We examine the expository signaling among the bone cells named osteoclast and osteoblast. Main functioning of osteoblasts is bone formation, whereas osteoclasts are bone removal cells. Mathematical framework for osteoporotic bone turnover comprising of the communication between osteoclasts and osteoblasts has been presented to exhibit the conditions for stability in bone turnover. The percentage ratios of the population of osteoblasts/osteoclasts have been determined via numerical simulations. The remedial upshots of targeting osteoporotic cells participating in such process are examined. From our analysis we have conclude that the role of external agents in treating the diseased bone can be better interpreted with the aid of a theoretical model.

Place, publisher, year, edition, pages
2019. article id 61
Keywords [en]
Bone remodeling, Osteoporosis, Stability analysis, Numerical simulations
National Category
Mathematics
Identifiers
URN: urn:nbn:se:su:diva-166707DOI: 10.1186/s13662-019-1986-7ISI: 000459046600001OAI: oai:DiVA.org:su-166707DiVA, id: diva2:1297291
Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-03-19Bibliographically approved

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Department of Biochemistry and BiophysicsScience for Life Laboratory (SciLifeLab)
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