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Prolonged Exposure to Bisphenol A from Single Dermal Contact Events
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry. University of Alberta, Canada.ORCID iD: 0000-0001-6265-4294
Number of Authors: 22017 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 51, no 17, p. 9940-9949Article in journal (Refereed) Published
Abstract [en]

Bisphenol A (BPA) is an endocrine disruptor frequently detected in human biofluids. Dermal absorption of BPA from thermal paper receipts occurs but BPA pharmacokinetics following dermal exposure is not understood. To compare the pharmacokinetics of dermal and dietary BPA exposure, six male participants handled simulated receipts containing relevant levels of BPA (isotope-labeled BPA-d(16)) for 5 min, followed by hand-washing 2 h later. Urine (0-48 h) and serum (0-7.5 h) were monitored for free and total BPA-d16. One week later, participants returned for a dietary administration with monitoring as above. One participant repeated the dermal administration with extended monitoring of urine (9 days) and serum (2 days). After dietary exposure, urine total BPA-d16 peaked within 5 h and quickly cleared within 24 h. After dermal exposure, cumulative excretion increased linearly for 2 days, and half the participants still had detectable urinary total BPA-d(16) after 1 week. The participant repeating the dermal exposure had detectable BPA-d(16) in urine for 9 days, showed linear cumulative excretion over 5 days, and had detectable free BPA-d(16) in serum. Proportions of free BPA-d(16) in urine following dermal exposure (0.71%-8.3% of total BPA-d(16)) were generally higher than following the dietary exposure (0.29%-1.4%). Compared to dietary BPA exposure, dermal absorption of BPA leads to prolonged exposure and may lead to higher proportions of unconjugated BPA in systemic circulation.

Place, publisher, year, edition, pages
2017. Vol. 51, no 17, p. 9940-9949
National Category
Environmental Engineering Earth and Related Environmental Sciences
Identifiers
URN: urn:nbn:se:su:diva-166169DOI: 10.1021/acs.est.7b03093ISI: 000410255800056PubMedID: 28759207OAI: oai:DiVA.org:su-166169DiVA, id: diva2:1298901
Available from: 2019-03-25 Created: 2019-03-25 Last updated: 2019-03-25Bibliographically approved

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