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Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. Stockholm University, Science for Life Laboratory (SciLifeLab). Oslo University Hospital, Norway.
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Number of Authors: 172019 (English)In: Journal of Extracellular Vesicles, ISSN 2001-3078, E-ISSN 2001-3078, Vol. 8, no 1, article id 1578116Article in journal (Refereed) Published
Abstract [en]

The prevalent porcine helminth, Ascaris suum, compromises pig health and reduces farm productivity worldwide. The closely related human parasite, A. lumbricoides, infects more than 800 million people representing a disease burden of 1.31 million disability-adjusted life years. The infections are often chronic in nature, and the parasites have a profound ability to modulate their hosts' immune responses. This study provides the first in-depth characterisation of extracellular vesicles (EVs) from different developmental stages and body parts of A. suum and proposes the role of these vesicles in the host-parasite interplay. The release of EVs from the third- (L3) and fourth-stage (L4) larvae and adults was demonstrated by transmission electron microscopy (TEM), and sequencing of EV-derived RNA identified a number of microRNAs (miRNAs) and transcripts of potential host immune targets, such as IL-13, IL-25 and IL-33, were identified. Furthermore, proteomics of EVs identified several proteins with immunomodulatory properties and other proteins previously shown to be associated with parasite EVs. Taken together, these results suggest that A. suum EVs and their cargo may play a role in host-parasite interactions. This knowledge may pave the way to novel strategies for helminth infection control and knowledge of their immune modulatory potential.

Place, publisher, year, edition, pages
2019. Vol. 8, no 1, article id 1578116
Keywords [en]
Ascaris suum, host-parasite interactions, extracellular vesicles, immunity, miRNA, proteomics
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-166609DOI: 10.1080/20013078.2019.1578116ISI: 000458750400001PubMedID: 30815237OAI: oai:DiVA.org:su-166609DiVA, id: diva2:1299203
Available from: 2019-03-26 Created: 2019-03-26 Last updated: 2019-03-26Bibliographically approved

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