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Kinetics of beta-N-methylamino-L-alanine (BMAA) and 2, 4-diaminobutyric acid (DAB) production by diatoms: the effect of nitrogen
Stockholm University, Faculty of Science, Department of Ecology, Environment and Plant Sciences.
Stockholm University, Faculty of Science, Department of Ecology, Environment and Plant Sciences.
Stockholm University, Faculty of Science, Department of Ecology, Environment and Plant Sciences.
Number of Authors: 42019 (English)In: European journal of phycology, ISSN 0967-0262, E-ISSN 1469-4433, Vol. 54, no 1, p. 115-125Article in journal (Refereed) Published
Abstract [en]

The neurotoxins beta-N-methylamino-L-alanine (BMAA) and 2,4-diaminobutyric acid (DAB) are produced by cyanobacteria, diatoms and dinoflagellates and have been detected in seafood worldwide. Our present knowledge of their metabolism or biosynthesis is limited. In this study, the production of BMAA and DAB as a function of time was monitored in five strains representing four species of diatoms, i.e. Phaeodactylum tricornutum, Thalassiosira weissflogii, Thalassiosira pseudonana and Navicula pelliculosa, previously identified as BMAA and DAB producers. Subsequently, three strains were selected and exposed to three nitrogen treatments - starvation, control (the standard concentration in f/2 medium) and enrichment, because BMAA metabolism has been suggested to be closely associated with cellular nitrogen metabolism in both cyanobacteria and diatoms. Chlorophyll a and total protein concentrations were also determined. Our results indicate that BMAA and DAB production in diatoms is species- and strain-specific. However, production might also be affected by stress, particularly as related to nitrogen starvation and cell density. Furthermore, this study shows a significant correlation between the production of the two neurotoxins which might further suggest common steps in the metabolic pathways.

Place, publisher, year, edition, pages
2019. Vol. 54, no 1, p. 115-125
Keywords [en]
beta-N-methylamino-L-alanine (BMAA), cell density, chlorophyll a, nitrogen stress, Navicula pelliculosa, Phaeodactylum tricornutum, Thalassiosira pseudonana, Thalassiosira weissflogii
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-166598DOI: 10.1080/09670262.2018.1508755ISI: 000458434900007OAI: oai:DiVA.org:su-166598DiVA, id: diva2:1300705
Available from: 2019-03-29 Created: 2019-03-29 Last updated: 2019-03-29Bibliographically approved

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Lage, SandraStröm, LinneaRydberg, Sara
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