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Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).ORCID iD: 0000-0001-9064-9222
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Catholic University of the Sacred Heart, Italy; Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Italy.
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Number of Authors: 82019 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 285, no 3, p. 255-271Article, review/survey (Refereed) Published
Abstract [en]

This review discusses the interplay between multimorbidity (i.e. co-occurrence of more than one chronic health condition in an individual) and functional impairment (i.e. limitations in mobility, strength or cognition that may eventually hamper a person's ability to perform everyday tasks). On the one hand, diseases belonging to common patterns of multimorbidity may interact, curtailing compensatory mechanisms and resulting in physical and cognitive decline. On the other hand, physical and cognitive impairment impact the severity and burden of multimorbidity, contributing to the establishment of a vicious circle. The circle may be further exacerbated by people's reduced ability to cope with treatment and care burden and physicians' fragmented view of health problems, which cause suboptimal use of health services and reduced quality of life and survival. Thus, the synergistic effects of medical diagnoses and functional status in adults, particularly older adults, emerge as central to assessing their health and care needs. Furthermore, common pathways seem to underlie multimorbidity, functional impairment and their interplay. For example, older age, obesity, involuntary weight loss and sedentarism can accelerate damage accumulation in organs and physiological systems by fostering inflammatory status. Inappropriate use or overuse of specific medications and drug-drug and drug-disease interactions also contribute to the bidirectional association between multimorbidity and functional impairment. Additionally, psychosocial factors such as low socioeconomic status and the direct or indirect effects of negative life events, weak social networks and an external locus of control may underlie the complex interactions between multimorbidity, functional decline and negative outcomes. Identifying modifiable risk factors and pathways common to multimorbidity and functional impairment could aid in the design of interventions to delay, prevent or alleviate age-related health deterioration; this review provides an overview of knowledge gaps and future directions.

Place, publisher, year, edition, pages
2019. Vol. 285, no 3, p. 255-271
Keywords [en]
multimorbidity, physical function, cognitive function, ageing
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:su:diva-167617DOI: 10.1111/joim.12843ISI: 000460674600002PubMedID: 30357990OAI: oai:DiVA.org:su-167617DiVA, id: diva2:1304460
Available from: 2019-04-12 Created: 2019-04-12 Last updated: 2019-04-12Bibliographically approved

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Calderón-Larrañaga, AmaiaMercer, S. W.
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