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3D Printed Porous Cellulose Nanocomposite Hydrogel Scaffolds
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
2019 (English)In: Journal of Visualized Experiments, ISSN 1940-087X, E-ISSN 1940-087X, no 146, article id e59401Article in journal (Refereed) Published
Abstract [en]

This work demonstrates the use of three-dimensional (3D) printing to produce porous cubic scaffolds using cellulose nanocomposite hydrogel ink, with controlled pore structure and mechanical properties. Cellulose nanocrystals (CNCs, 69.62 wt%) based hydrogel ink with matrix (sodium alginate and gelatin) was developed and 3D printed into scaffolds with uniform and gradient pore structure (110-1,100 µm). The scaffolds showed compression modulus in the range of 0.20-0.45 MPa when tested in simulated in vivo conditions (in distilled water at 37 °C). The pore sizes and the compression modulus of the 3D scaffolds matched with the requirements needed for cartilage regeneration applications. This work demonstrates that the consistency of the ink can be controlled by the concentration of the precursors and porosity can be controlled by the 3D printing process and both of these factors in return defines the mechanical properties of the 3D printed porous hydrogel scaffold. This process method can therefore be used to fabricate structurally and compositionally customized scaffolds according to the specific needs of patients.

Place, publisher, year, edition, pages
2019. no 146, article id e59401
Keywords [en]
Bioengineering, Issue 146, 3D printing, cellulose nanocrystals, hydrogel, porous scaffolds, biomedical applications, compressionmodulus
National Category
Composite Science and Engineering Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-168481DOI: 10.3791/59401ISI: 000466500600109OAI: oai:DiVA.org:su-168481DiVA, id: diva2:1308966
Available from: 2019-04-30 Created: 2019-04-30 Last updated: 2019-06-24Bibliographically approved

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Sultan, SaharMathew, Aji P.
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