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Internal Doses of Glycidol in Children and Estimation of Associated Cancer Risk
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Number of Authors: 42019 (English)In: Toxics, ISSN 2305-6304, Vol. 7, no 1, article id 7Article in journal (Refereed) Published
Abstract [en]

The general population is exposed to the genotoxic carcinogen glycidol via food containing refined edible oils where glycidol is present in the form of fatty acid esters. In this study, internal (in vivo) doses of glycidol were determined in a cohort of 50 children and in a reference group of 12 adults (non-smokers and smokers). The lifetime in vivo doses and intakes of glycidol were calculated from the levels of the hemoglobin (Hb) adduct N-(2,3-dihydroxypropyl)valine in blood samples from the subjects, demonstrating a fivefold variation between the children. The estimated mean intake (1.4 mu g/kg/day) was about two times higher, compared to the estimated intake for children by the European Food Safety Authority. The data from adults indicate that the non-smoking and smoking subjects are exposed to about the same or higher levels compared to the children, respectively. The estimated lifetime cancer risk (200/10(5)) was calculated by a multiplicative risk model from the lifetime in vivo doses of glycidol in the children, and exceeds what is considered to be an acceptable cancer risk. The results emphasize the importance to further clarify exposure to glycidol and other possible precursors that could give a contribution to the observed adduct levels.

Place, publisher, year, edition, pages
2019. Vol. 7, no 1, article id 7
Keywords [en]
glycidol, Hb adduct, N-(2, 3-dihydroxypropyl)valine, in vivo, cancer risk, UPLC, MS, MS
National Category
Occupational Health and Environmental Health Nutrition and Dietetics Other Chemistry Topics
Identifiers
URN: urn:nbn:se:su:diva-168441DOI: 10.3390/toxics7010007ISI: 000464046300001PubMedID: 30717263OAI: oai:DiVA.org:su-168441DiVA, id: diva2:1313388
Available from: 2019-05-03 Created: 2019-05-03 Last updated: 2019-11-28Bibliographically approved

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Aasa, JennyVryonidis, EfstathiosTörnqvist, Margareta
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