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Molecular evolution of uncoupling proteins and implications for brain function
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0003-0358-3865
Number of Authors: 22019 (English)In: Neuroscience Letters, ISSN 0304-3940, E-ISSN 1872-7972, Vol. 696, p. 140-145Article, review/survey (Refereed) Published
Abstract [en]

Uncoupling proteins (UCPs) belong to the mitochondrial anion carrier superfamily and catalyze important metabolic functions at the mitochondrial inner membrane. While the thermogenic role of UCP1 in brown fat of eutherian mammals is well established, the molecular functions of UCP1 in ectothermic vertebrates and of other UCP paralogs remain less clear. Here, we critically discuss the existence of brain UCPs and their potential roles. Applying phylogenetic classification of novel UCPs, we summarize the evidence for brain UCP1 among vertebrates, the role of UCP2 in specific brain areas, and the existence of brain-specific UCPs. The phylogenetic analyses and discussion on functional data should alert the scientific community that the molecular function of so-called UCP1 homologues is by far not clarified and possibly relates to neither thermogenesis nor mitochondrial uncoupling.

Place, publisher, year, edition, pages
2019. Vol. 696, p. 140-145
Keywords [en]
Mitochondrial uncoupling proteins, Brain, Thermogenesis, Phylogeny, Reactive oxygen species, BMCP
National Category
Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-168360DOI: 10.1016/j.neulet.2018.12.027ISI: 000463125800022PubMedID: 30582970OAI: oai:DiVA.org:su-168360DiVA, id: diva2:1314450
Available from: 2019-05-08 Created: 2019-05-08 Last updated: 2019-05-08Bibliographically approved

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Gaudry, Michael J.Jastroch, Martin
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