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Allergic contact dermatitis caused by hydroperoxides of limonene and dose-response relationship-A repeated open application test (ROAT) study
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
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Number of Authors: 72019 (English)In: Contact Dermatitis, ISSN 0105-1873, E-ISSN 1600-0536, Vol. 80, no 4, p. 208-216Article in journal (Refereed) Published
Abstract [en]

Background: Contact allergy to oxidized limonene, with hydroperoxides of limonene (Lim-OOHs) as the main allergens, is common. However, high proportions of weak positive and doubtful patch test reactions have been reported. Objectives: To determine the clinical relevance, elicitation threshold and dose-response relationship of Lim-OOHs in individuals with a positive or doubtful patch test reaction to standard Lim-OOHs 0.3% pet. Methods: A multicentre 3-week double-blind vehicle-controlled repeated open application test (ROAT) study with a simulated fine fragrance containing Lim-OOHs at 1260, 420 and 140 ppm, equal to a dose/area per application of Lim-OOHs of 3.0, 0.99 and 0.33 mu g/cm(2), was performed. Results: Among 11 subjects allergic to Lim-OOHs, 11 (100%), 7 (64%), and 3 (27%), respectively, reacted to the applied doses. No reactions were seen in 17 healthy controls exposed to the highest dose. This difference in reactivity was statistically significant (P < 0.0001). Among 13 subjects with doubtful patch test reactions to Lim-OOHs, two (15%) had positive ROAT reactions to the highest Lim-OOH dose applied (P = 0.36 as compared with controls). Conclusions: Contact allergy to Lim-OOHs is of clinical relevance in patients with positive patch test reactions. A doubtful patch test reaction to Lim-OOHs 0.3% pet. can be of clinical relevance.

Place, publisher, year, edition, pages
2019. Vol. 80, no 4, p. 208-216
Keywords [en]
allergic contact dermatitis, clinical relevance, contact allergy, dose-response relationship, fragrance substance, limonene hydroperoxides, oxidized limonene, ROAT
National Category
Dermatology and Venereal Diseases Analytical Chemistry
Identifiers
URN: urn:nbn:se:su:diva-168597DOI: 10.1111/cod.13168ISI: 000461882500002PubMedID: 30378136OAI: oai:DiVA.org:su-168597DiVA, id: diva2:1315725
Available from: 2019-05-14 Created: 2019-05-14 Last updated: 2019-05-14Bibliographically approved

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