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Hypoxia Induced by Vascular Damage at High Doses Could Compromise the Outcome of Radiotherapy
Stockholm University, Faculty of Science, Department of Physics.
Stockholm University, Faculty of Science, Department of Physics. Karolinska Institute, Sweden.ORCID iD: 0000-0002-7101-240X
2019 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 39, no 5, p. 2337-2340Article in journal (Refereed) Published
Abstract [en]

Background/Aim: This study investigated the impact of temporary vascular collapse on tumour control probability (TCP) in stereotactic body radiotherapy (SBRT), taking into account different radiosensitivities of chronically and acutely hypoxic cells. Materials and Methods: Three-dimensional tumours with heterogeneous oxygenation were simulated assuming different fractions of collapsed vessels at every treatment fraction. The modelled tumours contained a chronically hypoxic subvolume of 30-60% of the tumour diameter, and a hypoxic fraction ≤5 mm Hg of 30-50%. The rest of the tumours were well-oxygenated at the start of the simulated treatment. Results: For all simulated cases, the largest reduction in TCP from 97% to 2% was found in a tumour with a small chronically hypoxic core treated with 60 Gy in eight fractions and assuming a treatment-induced vascular collapse of 35% in the well-oxygenated region. Conclusion: The timing of SBRT fractions should be considered together with the tumour oxygenation to avoid loss of TCP in SBRT.

Place, publisher, year, edition, pages
2019. Vol. 39, no 5, p. 2337-2340
Keywords [en]
Hypoxia, vascular damage, stereotactic body radiotherapy, SBRT, tumour control probability, TCP, tumour oxygenation
National Category
Cancer and Oncology Physical Sciences
Identifiers
URN: urn:nbn:se:su:diva-168923DOI: 10.21873/anticanres.13350ISI: 000469427800011OAI: oai:DiVA.org:su-168923DiVA, id: diva2:1316103
Available from: 2019-05-15 Created: 2019-05-15 Last updated: 2019-06-24Bibliographically approved

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Kjellsson Lindblom, EmelyDasu, AlexandruToma-Dasu, Iuliana
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