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Regulation of immune and tissue homeostasis by Drosophila POU factors
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0001-9875-8829
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Number of Authors: 22019 (English)In: Insect Biochemistry and Molecular Biology, ISSN 0965-1748, E-ISSN 1879-0240, Vol. 109, p. 24-30Article in journal (Refereed) Published
Abstract [en]

The innate immune system of insects deploys both cellular and humoral reactions in immunocompetent tissues for protection of insects against a variety of infections, including bacteria, fungi, and viruses. Transcriptional regulation of genes encoding antimicrobial peptides (AMPs), cytokines, and other immune effectors plays a pivotal role in maintenance of immune homeostasis both prior to and after infections. The POU/Oct transcription factor family is a subclass of the homeodomain proteins present in all metazoans. POU factors are involved in regulation of development, metabolism and immunity. Their role in regulation of immune functions has recently become evident, and involves control of tissue-specific, constitutive expression of immune effectors in barrier epithelia as well as positive and negative control of immune responses in gut and fat body. In addition, they have been shown to affect the composition of gut microbiota and play a role in regulation of intestinal stem cell activities. In this review, we summarize the current knowledge of how POU transcription factors control Drosophila immune homeostasis in healthy and infected insects. The role of POU factor isoform specific regulation of stem cell activities in Drosophila and mammals is also discussed.

Place, publisher, year, edition, pages
2019. Vol. 109, p. 24-30
Keywords [en]
Antimicrobial peptides, Epithelium regeneration, Innate immunity, Microbiota, Oct factors, Transcriptional regulation
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-170101DOI: 10.1016/j.ibmb.2019.04.003ISI: 000470192100003PubMedID: 30954681OAI: oai:DiVA.org:su-170101DiVA, id: diva2:1334584
Available from: 2019-07-03 Created: 2019-07-03 Last updated: 2019-07-03Bibliographically approved

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