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Race reporting and disparities in clinical trials on Alzheimer's disease: A systematic review
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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Number of Authors: 102019 (English)In: Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, E-ISSN 1873-7528, Vol. 101, p. 122-128Article, review/survey (Refereed) Published
Abstract [en]

Introduction: Race is an important health determinant and should adequately be considered in research and drug development protocols targeting Alzheimer's disease (AD).

Methods: A systematic review of available randomized controlled trials (RCTs) on the currently marketed treatments for AD was conducted with the aim of 1) documenting the reporting of race, and 2) exploring the impact of race on the efficacy and safety/tolerability of the considered medications.

Results: Overall, 59.2% of the 49 retained RCTs reported information concerning the race of participants. Only a striking minority of enrolled patients was constituted of blacks and Hispanics. None on the retained studies reported results on the efficacy and safety/tolerability of the tested treatment separately for racial groups nor performed sensitivity analyses accounting for the race of participants.

Discussion: Race has insufficiently been reported in previous interventional studies on AD. Its potential association with the effectiveness and safety/tolerability of the tested medications has completely been neglected.

Place, publisher, year, edition, pages
2019. Vol. 101, p. 122-128
Keywords [en]
Alzheimer's disease, Dementia, Race, Randomized controlled trial, External validity, Precision medicine
National Category
Geriatrics Social and Clinical Pharmacy
Identifiers
URN: urn:nbn:se:su:diva-170097DOI: 10.1016/j.neubiorev.2019.03.020ISI: 000470338900009PubMedID: 30946856OAI: oai:DiVA.org:su-170097DiVA, id: diva2:1334623
Available from: 2019-07-03 Created: 2019-07-03 Last updated: 2019-07-03Bibliographically approved

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