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Spatiotemporal structure of cell fate decisions in murine neural crest
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Number of Authors: 282019 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 364, no 6444, article id eaas9536Article in journal (Refereed) Published
Abstract [en]

Neural crest cells are embryonic progenitors that generate numerous cell types in vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become biased toward neuronal lineages when they delaminate from the neural tube, whereas cranial neural crest cells acquire ectomesenchyme potential dependent on activation of the transcription factor Twist1. The choices that neural crest cells make to become sensory, glial, autonomic, or mesenchymal cells can be formalized as a series of sequential binary decisions. Each branch of the decision tree involves initial coactivation of bipotential properties followed by gradual shifts toward commitment. Competing fate programs are coactivated before cells acquire fate-specific phenotypic traits. Determination of a specific fate is achieved by increased synchronization of relevant programs and concurrent repression of competing fate programs.

Place, publisher, year, edition, pages
2019. Vol. 364, no 6444, article id eaas9536
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Biological Sciences
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URN: urn:nbn:se:su:diva-170081DOI: 10.1126/science.aas9536ISI: 000471079600001PubMedID: 31171666OAI: oai:DiVA.org:su-170081DiVA, id: diva2:1334988
Available from: 2019-07-03 Created: 2019-07-03 Last updated: 2019-07-03Bibliographically approved

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Soldatov, RuslanKaucka, MarketaKastriti, Maria EleniPetersen, JulianEnglmaier, LukasAkkuratova, NataliaYang, YunshiDyachuk, ViacheslavHilscher, Markus M.Yokota, ChikaQian, XiaoyanNilsson, MatsConsalez, Gian GiacomoKharchenko, Peter V.
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