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On the role of macrophages in the control of adipocyte energy metabolism
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0003-0319-3509
Number of Authors: 12019 (English)In: Endocrine Connections, ISSN 2049-3614, E-ISSN 2049-3614, Vol. 8, no 6, p. r105-R121Article, review/survey (Refereed) Published
Abstract [en]

The crosstalk between macrophages (MF) and adipocytes within white adipose tissue (WAT) influences obesity-associated insulin resistance and other associated metabolic disorders, such as atherosclerosis, hypertension and type 2 diabetes. MF infiltration is increased in WAT during obesity, which is linked to decreased mitochondrial content and activity. The mechanistic interplay between MF and mitochondrial function of adipocytes is under intense investigation, as MF and inflammatory pathways exhibit a pivotal role in the reprogramming of WAT metabolism in physiological responses during cold, fasting and exercise. Thus, the underlying immunometabolic pathways may offer therapeutic targets to correct obesity and metabolic disease. Here, I review the current knowledge on the quantity and the quality of human adipose tissue macrophages (ATM phi) and their impact on the bioenergetics of human adipocytes. The effects of ATM phi and their secreted factors on mitochondrial function of white adipocytes are discussed, including recent research on MF as part of an immune signaling cascade involved in the 'browning' of WAT, which is defined as the conversion from white, energy-storing adipocytes into brown, energy-dissipating adipocytes.

Place, publisher, year, edition, pages
2019. Vol. 8, no 6, p. r105-R121
Keywords [en]
inflammation, oxidative phosphorylation, glycolysis, cellular energy metabolism, obesity, diabetes
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-170885DOI: 10.1530/EC-19-0016ISI: 000472586000002PubMedID: 31085768OAI: oai:DiVA.org:su-170885DiVA, id: diva2:1338515
Available from: 2019-07-23 Created: 2019-07-23 Last updated: 2019-07-23Bibliographically approved

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