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A neurotoxin that specifically targets Anopheles mosquitoes
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
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Number of Authors: 92019 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 10, article id 2869Article in journal (Refereed) Published
Abstract [en]

Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets anopheline mosquitoes. Isolation of PMP1 from Paraclostridium bifermentans strains collected in anopheline endemic areas on two continents indicates it is widely distributed. The toxin likely evolved from an ancestral form that targets the nervous system of similar organisms, using a common mechanism that disrupts SNARE-mediated exocytosis. It cleaves the mosquito syntaxin and employs a unique receptor recognition strategy. Our research has an important impact on the study of the evolution of clostridial neurotoxins and provides the basis for the use of P. bifermentans strains and PMP1 as innovative, environmentally friendly approaches to reduce malaria through anopheline control.

Place, publisher, year, edition, pages
2019. Vol. 10, article id 2869
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Biological Sciences
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URN: urn:nbn:se:su:diva-170839DOI: 10.1038/s41467-019-10732-wISI: 000473132200033PubMedID: 31253776OAI: oai:DiVA.org:su-170839DiVA, id: diva2:1339308
Available from: 2019-07-29 Created: 2019-07-29 Last updated: 2019-07-29Bibliographically approved

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