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Botulinum and Tetanus Neurotoxins
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Lund University, Sweden.ORCID iD: 0000-0003-4777-3417
Number of Authors: 32019 (English)In: Annual Review of Biochemistry, ISSN 0066-4154, E-ISSN 1545-4509, Vol. 88, p. 811-837Article in journal (Refereed) Published
Abstract [en]

Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic vesicle exocytosis. These toxins also have distinct features: BoNTs exist within a progenitor toxin complex (PTC), which protects the toxin and facilitates its absorption in the gastrointestinal tract, whereas TeNT is uniquely transported retrogradely within motor neurons. Our increasing knowledge of these toxins has allowed the development of engineered toxins for medical uses. The discovery of new BoNTs and BoNT-like proteins provides additional tools to understand the evolution of the toxins and to engineer toxin-based therapeutics. This review summarizes the progress on our understanding of BoNTs and TeNT, focusing on the PTC, receptor recognition, new BoNT-like toxins, and therapeutic toxin engineering.

Place, publisher, year, edition, pages
2019. Vol. 88, p. 811-837
Keywords [en]
botulinum neurotoxin, tetanus neurotoxin, bacterial toxin, toxin, clostridium, protein engineering
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-171201DOI: 10.1146/annurev-biochem-013118-111654ISI: 000472818600030PubMedID: 30388027OAI: oai:DiVA.org:su-171201DiVA, id: diva2:1339887
Available from: 2019-07-31 Created: 2019-07-31 Last updated: 2019-07-31Bibliographically approved

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