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Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. New York University Abu Dhabi, United Arab Emirates.
Number of Authors: 22019 (English)In: Molecular Biology of the Cell, ISSN 1059-1524, E-ISSN 1939-4586, Vol. 30, no 15, p. 1781-1785Article in journal (Refereed) Published
Abstract [en]

The emerging role of cytoskeletal proteins in the cell nucleus has become a new frontier in cell biology. Actin and actin-binding proteins regulate chromatin and gene expression, but importantly they are beginning to be essential players in genome organization. These actin-based functions contribute to genome stability and integrity while affecting DNA replication and global transcription patterns. This is likely to occur through interactions of actin with nuclear components including nuclear lamina and subnuclear organelles. An exciting future challenge is to understand how these actin-based genome-wide mechanisms may regulate development and differentiation by interfering with the mechanical properties of the cell nucleus and how regulated actin polymerization plays a role in maintaining nuclear architecture. With a special focus on actin, here we summarize how cytoskeletal proteins operate in the nucleus and how they may be important to consolidate nuclear architecture for sustained gene expression or silencing.

Place, publisher, year, edition, pages
2019. Vol. 30, no 15, p. 1781-1785
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-171733DOI: 10.1091/mbc.E18-10-0645ISI: 000475726700001PubMedID: 31306096OAI: oai:DiVA.org:su-171733DiVA, id: diva2:1349964
Available from: 2019-09-10 Created: 2019-09-10 Last updated: 2019-09-10Bibliographically approved

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Percipalle, Piergiorgio
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