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Reconsolidation of a well-learned instrumental memory
University of Birmingham, United Kingdom.ORCID iD: 0000-0002-4275-5378
2014 (English)In: Learning & memory (Cold Spring Harbor, N.Y.), ISSN 1072-0502, E-ISSN 1549-5485, Vol. 21, no 9, p. 468-477Article in journal (Refereed) Published
Abstract [en]

Once consolidated, memories are dynamic entities that go through phases of instability in order to be updated with new information, via a process of reconsolidation. The phenomenon of reconsolidation has been demonstrated in a wide variety of experimental paradigms. However, the memories underpinning instrumental behaviors are currently not believed to reconsolidate. We show that well-learned lever pressing in rats does undergo reconsolidation, which can be disrupted by systemic administration of the noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist (+)-5-methyl-10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) when administered prior to a switch to a variable, but not fixed, ratio schedule. Disruption of reconsolidation resulted in a reduction in long-term lever pressing performance and diminished the sensitivity of behavior to contingency change. Further investigation demonstrated that expression of the reconsolidation impairment was not affected by outcome value, implying a deficit in a stimulus–response (S–R) process. The ability to disrupt the performance of well-learned instrumental behaviors is potentially of great importance in the development of reconsolidation-based clinical treatments for conditions that involve compulsive seeking behaviors.

Place, publisher, year, edition, pages
2014. Vol. 21, no 9, p. 468-477
National Category
Psychology Neurosciences
Identifiers
URN: urn:nbn:se:su:diva-172925DOI: 10.1101/lm.035543.114PubMedID: 25135195OAI: oai:DiVA.org:su-172925DiVA, id: diva2:1351253
Available from: 2019-09-13 Created: 2019-09-13 Last updated: 2019-09-16Bibliographically approved

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