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Efficacy of the Small Step Program in a Randomized Controlled Trial for Infants under 12 Months Old at Risk of Cerebral Palsy (CP) and Other Neurological Disorders
Stockholm University, Faculty of Humanities, Department of Linguistics. Karolinska Institutet, Sweden.
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Number of Authors: 72019 (English)In: Journal of Clinical Medicine, ISSN 2077-0383, Vol. 8, no 7, article id 1016Article in journal (Refereed) Published
Abstract [en]

The objective was to evaluate the effects of the Small Step Program on general development in children at risk of cerebral palsy (CP) or other neurodevelopmental disorders. A randomized controlled trial compared Small Step with Standard Care in infants recruited at 4-9 months of corrected age (CA). The 35-week intervention targeted mobility, hand use, and communication during distinct periods. The Peabody Developmental Motor Scales(2ed) (PDMS-2) was the primary outcome measure. For statistical analysis, a general linear model used PDMS-2 as the main outcome variable, together with a set of independent variables. Thirty-nine infants were randomized to Small Step (n = 19, age 6.3 months CA (1.62 SD)) or Standard Care (n = 20, age 6.7 months CA (1.96 SD)). Administering PDMS-2 at end of treatment identified no group effect, but an interaction between group and PDMS-2 at baseline was found (p < 0.02). Development was associated with baseline assessments in the Standard Care group, while infants in the Small Step group developed independent of the baseline level, implying that Small Step helped the most affected children to catch up by the end of treatment. This result was sustained at 2 years of age for PDMS-2 and the PEDI mobility scale.

Place, publisher, year, edition, pages
2019. Vol. 8, no 7, article id 1016
Keywords [en]
early intervention, cerebral palsy, development, other neurological disorder, gross motor function, upper limb function, communication
National Category
Neurosciences Pediatrics
Identifiers
URN: urn:nbn:se:su:diva-173052DOI: 10.3390/jcm8071016ISI: 000479003300101PubMedID: 31336705OAI: oai:DiVA.org:su-173052DiVA, id: diva2:1353440
Available from: 2019-09-23 Created: 2019-09-23 Last updated: 2019-09-23Bibliographically approved

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Almeida, RitaTedroff, KristinaLöwing, Kristina
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