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Thyroid disruption properties of three indoor dust chemicals tested in Silurana tropicalis tadpoles
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
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Number of Authors: 52019 (English)In: Journal of Applied Toxicology, ISSN 0260-437X, E-ISSN 1099-1263, Vol. 39, no 9, p. 1248-1256Article in journal (Refereed) Published
Abstract [en]

Indoor dust contains a multitude of industrial chemicals, and ingestion of dust is considered an important exposure route to organic contaminants. Some of these contaminants have been shown to interfere with the thyroid system, which may result in significant consequences on public health. The amphibian metamorphosis is a thyroid hormone-dependent process, which can be used as an in vivo model for studies on thyroid hormone-disrupting potency. Three contaminants of indoor dust were tested on metamorphosing Silurana (Xenopus) tropicalis tadpoles. The tested chemicals were Tris (1,3-dichloroisopropyl) phosphate (TDCiPP), tetrabromobisphenol-A (TBBPA) and propylparaben (PrP). Measurements reflecting general growth, development progress and thyroid epithelial cell height were performed on the exposed tadpoles as well as chemical analyses of the exposure water. It was shown that TDCiPP acts as a thyroid hormone-disrupting chemical in metamorphosing tadpoles by causing increased epithelial cell height in thyroid glands after exposure to a nominal concentration of 0.010 mg/L and in higher concentrations. TBBPA caused reductions in general growth of tadpoles at the nominal concentration 0.125 mg/L, and PrP caused acute toxicity at the nominal concentration 12.5 mg/L. However, no evident indications of specific thyroid-disrupting effects caused by TBBPA or PrP were observed.

Place, publisher, year, edition, pages
2019. Vol. 39, no 9, p. 1248-1256
Keywords [en]
metamorphosis, propyl paraben, Silurana tropicalis, TBBPA, TDCiPP, thyroid
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:su:diva-173086DOI: 10.1002/jat.3810ISI: 000481847900001PubMedID: 31066086OAI: oai:DiVA.org:su-173086DiVA, id: diva2:1358474
Available from: 2019-10-07 Created: 2019-10-07 Last updated: 2019-10-07Bibliographically approved

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Carlsson, GunnarPohl, JohannesAthanassiadis, IoannisWeiss, Jana
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