Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
2-acetylaminofluorene: metabolism and effects on drug-metabolizing enzymes
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
1985 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

2-Acetylaminofluorene has been found to have two different kinds of effects on drug-metabolizing enzymes in rat liver :

1. Short-term treatment with this compound induces the level of microsomal epoxide hydrolase and cytochromes P-450b+e, c, d and PB/PCN-E, with a concominant increase in the metabolism of 2-acetylaminoflurene itself. Cytochromes P-450c and d have been found to be the most effective isozymes in both catalyzing ring- and N-hydroxylation of 2-acetylaminofluorene. All other isozymes tested have a lower activity, but also unique metabolitte patterns in the reconstituted system. 2-Aminofluorene, the deacetylated product, is the metabolite responsible for the induction of cytochrome P-450c, while the parent compound and other metabolites seem to be more effective in inducing other isozymes of cytochrome P-450 and microsomal epoxide hydrolase. Also increased to a small extent are cytosolic glutathione transferase and DT-diaphorase activities.

2. Long-term dietary exposure to 2-acetylaminofluorene, resulting in hepatocyte nodules, gives a different picture, i.e., decreases in the total content of cytochrome P-450 and and a number of cytochrome P-450-dependent activities, including ring and N-hydroxylation of 2-acetylaminofluorene itself.

The activities of microsomal epoxide hydrolase, cytosolic glutathione transferase, UDP-glucuronyl transferase and cytosolic DT-diaphorase are dramatically increased in nodules.

Place, publisher, year, edition, pages
Stockholm: Stockholm University, 1985. , p. 78
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-174608Libris ID: 7608686ISBN: 91-7146-654-1 (print)OAI: oai:DiVA.org:su-174608DiVA, id: diva2:1358763
Public defence
Hörsal G, Biologilaboratoriet, Svante Arrhenius väg 12, Stockholm
Note

Härtill 5 uppsatser

Available from: 2019-10-08 Created: 2019-10-08 Last updated: 2019-12-10Bibliographically approved

Open Access in DiVA

No full text in DiVA

By organisation
Department of Biochemistry and Biophysics
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar

isbn
urn-nbn

Altmetric score

isbn
urn-nbn
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf