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Aneuploidy in yeast: Segregation error or adaptation mechanism?
Stockholm University, Faculty of Science, Department of Zoology.ORCID iD: 0000-0002-7639-6131
Stockholm University, Faculty of Science, Department of Zoology.ORCID iD: 0000-0002-8530-0656
Number of Authors: 22019 (English)In: Yeast, ISSN 0749-503X, E-ISSN 1097-0061, Vol. 36, no 9, p. 525-539Article in journal (Refereed) Published
Abstract [en]

Aneuploidy is the loss or gain of chromosomes within a genome. It is often detrimental and has been associated with cell death and genetic disorders. However, aneuploidy can also be beneficial and provide a quick solution through changes in gene dosage when cells face environmental stress. Here, we review the prevalence of aneuploidy in Saccharomyces, Candida, and Cryptococcus yeasts (and their hybrid offspring) and analyse associations with chromosome size and specific stressors. We discuss how aneuploidy, a segregation error, may in fact provide a natural route for the diversification of microbes and enable important evolutionary innovations given the right ecological circumstances, such as the colonisation of new environments or the transition from commensal to pathogenic lifestyle. We also draw attention to a largely unstudied cross link between hybridisation and aneuploidy. Hybrid meiosis, involving two divergent genomes, can lead to drastically increased rates of aneuploidy in the offspring due to antirecombination and chromosomal missegregation. Because hybridisation and aneuploidy have both been shown to increase with environmental stress, we believe it important and timely to start exploring the evolutionary significance of their co-occurrence.

Place, publisher, year, edition, pages
2019. Vol. 36, no 9, p. 525-539
Keywords [en]
adaptation, aneuploidy, environmental stress, hybridisation, yeast
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-173011DOI: 10.1002/yea.3427ISI: 000479960500001PubMedID: 31199875OAI: oai:DiVA.org:su-173011DiVA, id: diva2:1360202
Available from: 2019-10-11 Created: 2019-10-11 Last updated: 2019-10-11Bibliographically approved

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