Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Mechanisms of muscarinic feedback regulation of acetylcholine release in rat hippocampus: an in vitro study
Stockholm University, Faculty of Science.
1982 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The present study on dilute suspensions of synaptosomes from rat hippocampus yields evidence that feedback regulation of acetylcholine release in this preparation is exerted by a muscarinic autoreceptor localized on the cholinergic nerve ending itself. A possible model for the sequence of events which may take place at the cholinergic nerve ending is presented. Fresh surgical material has been used to demonstrate that the release of acetylcholine in the human cerebral cortex is also regulated by presynaptic muscarinic receptors. An in vitro test system for the study of drugs which affect the release of acetylcholine has been developed. This system was used to examine the effect of a novel cholinergic ligand, N-methyl-N(l-methyl-4-pyrrolidino-2-butynyl) acetamide, on 3 the release of H-acetylcholine. This ligand appears to act as a presynaptic antagonist and a postsynaptic agonist.

Place, publisher, year, edition, pages
Stockholm: Stockholm University, 1982. , p. 46
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-174900Libris ID: 7608298ISBN: 91-7146-222-8 (print)OAI: oai:DiVA.org:su-174900DiVA, id: diva2:1360620
Public defence
1982-10-22, Föreläsningssalen 3Ö, Arrheniuslaboratoriet, Bergiusvägen 65, Stockholm, 10:00
Note

Härtill 10 uppsatser

Available from: 2019-10-14 Created: 2019-10-14 Last updated: 2019-12-05Bibliographically approved

Open Access in DiVA

No full text in DiVA

By organisation
Faculty of Science
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

isbn
urn-nbn

Altmetric score

isbn
urn-nbn
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf