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Convergence of EGFR glioblastoma mutations: evolution and allostery rationalizing targeted therapy
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).ORCID iD: 0000-0003-1927-555X
Number of Authors: 12019 (English)In: Molecular & Cellular Oncology, E-ISSN 2372-3556, Vol. 6, no 5, article id e1630798Article in journal (Refereed) Published
Abstract [en]

EGFR mutations display striking organ-site asymmetry and heterogeneity. We have shown that structurally diverse extracellular mutations, typical of glioblastomas, converge to a similar intermediate conformation, which can be synergistically targeted extra- and intracelullarly by antibody mAb806 and type-II kinase inhibitors. Our findings reveal convergence behind heterogeneity, paving the way for allostery-based co-targeting.

Place, publisher, year, edition, pages
2019. Vol. 6, no 5, article id e1630798
Keywords [en]
EGFR, ectomutations, convergence, mAb806, kinase inhibitors
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-174993DOI: 10.1080/23723556.2019.1630798ISI: 000485086600013PubMedID: 31528699OAI: oai:DiVA.org:su-174993DiVA, id: diva2:1361507
Available from: 2019-10-16 Created: 2019-10-16 Last updated: 2019-10-16Bibliographically approved

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