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Bile acids adsorption by chitoan-fumed silica enterosorbent
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK). National Academy of Sciences of Ukraine, Ukraine.
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK).
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Number of Authors: 52019 (English)In: Colloid and Interface Science Communications, ISSN 2215-0382, Vol. 32, article id 100194Article in journal (Refereed) Published
Abstract [en]

Hybrid composites from chitosan and fumed silica were synthesized and applied for the adsorption of bile acids (BA), e.g. cholic (CA) and taurocholic (TCA) acids. The chitosan immobilization was confirmed by infrared spectroscopy and the corresponding stability of the composites was confirmed by tests with the analytical reagent ninhydrin. The effects of adsorption parameters such as initial concentration of BA and pH were evaluated. The synthesized composite shows higher affinity and adsorption capacity toward TCA in comparison to CA. The results of equilibrium study for BA adsorption by the synthesized composite were analyzed by application of Langmuir, Freundlich and Temkin isotherm models. Adsorption capacity of chitosan-fumed silica composite was 97 mu mol/g for TCA and 43 mu mol/g for CA based on the applied Freundlich isoterm model. Our results show the potential of biopolymeric-inorganic composites for application as efficient enterosorbent in medical practice.

Place, publisher, year, edition, pages
2019. Vol. 32, article id 100194
Keywords [en]
Bile acids, Chitosan, Silica, Enterosorbent, Cholic acid, Taurocholic acid
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-174957DOI: 10.1016/j.colcom.2019.100194ISI: 000485985500004OAI: oai:DiVA.org:su-174957DiVA, id: diva2:1365037
Available from: 2019-10-23 Created: 2019-10-23 Last updated: 2019-10-23Bibliographically approved

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Budnyak, Tetyana M.Slabon, Adam
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