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Recent CPP-based applications in medicine
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. University of Tartu, Estonia.
Number of Authors: 22019 (English)In: Expert Opinion on Drug Delivery, ISSN 1742-5247, E-ISSN 1744-7593, Vol. 16, no 11, p. 1183-1191Article, review/survey (Refereed) Published
Abstract [en]

Introduction: Cell-penetrating peptides (CPP) offer versatile tools for the field of drug delivery and development of macromolecular therapeutics. These tools have matured into applications that allow the use of proteins, nucleic acid, peptides, imaging agents, and low molecular weight drugs as therapeutic entities.

Areas covered: The progress of the field is discussed in the current review, with the examples from a recent couple of years, in the utilization of CPPs in medicine. Specific focus is on the research articles that include applications that have direct translational value. Progress with protein mimicry and its recent leap in medicine is discussed with special attention, but also achievements with nanoformulation and drug targeting is presented.

Expert opinion: The opinion section discusses some of the limitations and shortcomings, proposing the areas where more effort should be invested in order to increase the translational value of the current preclinical research.

Place, publisher, year, edition, pages
2019. Vol. 16, no 11, p. 1183-1191
Keywords [en]
Cell penetrating peptides, CPP, drug delivery, nanotechnology, protein mimicry, peptidomimetics
National Category
Biological Sciences Neurosciences
Identifiers
URN: urn:nbn:se:su:diva-175071DOI: 10.1080/17425247.2019.1665021ISI: 000486742600001PubMedID: 31526146OAI: oai:DiVA.org:su-175071DiVA, id: diva2:1368124
Available from: 2019-11-06 Created: 2019-11-06 Last updated: 2019-11-06Bibliographically approved

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