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Perfluoroalkyl Acids (PFAAs) in Children's Serum and Contribution from PFAA-Contaminated Drinking Water
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry.
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Number of Authors: 82019 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 53, no 19, p. 11447-11457Article in journal (Refereed) Published
Abstract [en]

We investigated associations between serum perfluoroalkyl acid (PFAA) concentrations in children aged 4, 8, and 12 years (sampled in 2008-2015; n = 57, 55, and 119, respectively) and exposure via placental transfer, breastfeeding, and ingestion of PFAA-contaminated drinking water. Sampling took place in Uppsala County, Sweden, where the drinking water has been historically contaminated with perfluorobutanesulfonate (PFBS), perfluorohexanesulfonate (PFHxS), perfluorooctanesulfonate (PFOS), perfluoroheptanoate (PFHpA), and perfluorooctanoate (PFOA). PFOS showed the highest median concentrations in serum (3.8-5.3 ng g(-1) serum), followed by PFHxS (1.6-5.0 ng g(-1) serum), PFOA (2.0-2.5 ng g(-1) serum), and perfluorononanoate (PFNA) (0.59-0.69 ng g(-1) serum) in children. Including all children, serum PFOA, PFHxS, and PFOS concentrations (adjusted mean), respectively, per unit (ng g(-1) serum) of increase in the maternal serum level (at delivery), the associations being strongest for 4 year-old children. PFHxS and PFOS significantly increased 3.9 and 3.8%, respectively, per month of nursing, with the highest increase for 4 year-olds. PFOA, PFBS, PFHxS, and PFOS increased 1.2, 207, 7.4, and 0.93%, respectively, per month of cumulative drinking water exposure. Early life exposure to PFOA, PFHxS, and PFOS is an important determinant of serum concentrations in children, with the strongest influence on younger ages. Drinking water with low to moderate PFBS, PFHxS, PFOS, and PFOA contamination is an important source of exposure for children with background exposure from other sources.

Place, publisher, year, edition, pages
2019. Vol. 53, no 19, p. 11447-11457
National Category
Earth and Related Environmental Sciences Environmental Engineering
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URN: urn:nbn:se:su:diva-175737DOI: 10.1021/acs.est.9b01746ISI: 000488993500043PubMedID: 31476116OAI: oai:DiVA.org:su-175737DiVA, id: diva2:1369234
Available from: 2019-11-11 Created: 2019-11-11 Last updated: 2019-11-11Bibliographically approved

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Benskin, Jonathan P.Sandblom, OskarAhrens, LutzWiberg, Karin
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