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Advancing Solutions to the Carbohydrate Sequencing Challenge
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Number of Authors: 112019 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 141, no 37, p. 14463-14479Article, review/survey (Refereed) Published
Abstract [en]

Carbohydrates possess a variety of distinct features with stereochemistry playing a particularly important role in distinguishing their structure and function. Monosaccharide building blocks are defined by a high density of chiral centers. Additionally, the anomericity and regiochemistry of the glycosidic linkages carry important biological information. Any carbohydrate-sequencing method needs to be precise in determining all aspects of this stereodiversity. Recently, several advances have been made in developing fast and precise analytical techniques that have the potential to address the stereochemical complexity of carbohydrates. This perspective seeks to provide an overview of some of these emerging techniques, focusing on those that are based on NMR and MS-hybridized technologies including ion mobility spectrometry and IR spectroscopy.

Place, publisher, year, edition, pages
2019. Vol. 141, no 37, p. 14463-14479
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Chemical Sciences
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URN: urn:nbn:se:su:diva-175712DOI: 10.1021/jacs.9b06406ISI: 000487180200001PubMedID: 31403778OAI: oai:DiVA.org:su-175712DiVA, id: diva2:1369914
Available from: 2019-11-13 Created: 2019-11-13 Last updated: 2019-11-13Bibliographically approved

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Barran, Perdita E.Pagel, KevinSeeberger, Peter H.Eyers, Claire E.Boons, Geert-JanWidmalm, Göran
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