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Adherence to a healthy lifestyle counteracts the negative effects of risk factors on all-cause mortality in the oldest-old
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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Number of Authors: 82019 (English)In: Aging, ISSN 1945-4589, E-ISSN 1945-4589, Vol. 11, no 18, p. 7605-7619Article in journal (Refereed) Published
Abstract [en]

In the study, we examined the extent to which the harmful effects of risk factors on all-cause mortality can be counteracted by healthy lifestyle practices in the oldest-old (80 years of age and older). A total of 17,660 oldest-old from China were followed up for up to 10 years. The data were analyzed using the Cox proportional hazard model with adjustment for potential confounders. We found that having a rural residence, not being married, having lower economic status, physical disability, impaired cognitive function, or comorbidity were all associated with an elevated risk of mortality. Using these factors, we computed a weighted risk score. Because never smoking, never drinking, doing physical exercise, having an ideal diet, and a normal weight were independently associated with lower mortality, we also combined them to compute a weighted protection score. Both scores were divided into lowest, middle, and highest groups using their tertiles. In joint effect analyses, participants with the combined highest-risk score and lowest-protection score profile had a nearly threefold higher joint death risk. These analyses show that adherence to a healthy lifestyle counteracts the negative effect of risk factors on all-cause mortality in the oldest-old by more than 20%.

Place, publisher, year, edition, pages
2019. Vol. 11, no 18, p. 7605-7619
Keywords [en]
risk factors, lifestyle, all-cause mortality, cohort study
National Category
Biological Sciences Clinical Medicine Health Sciences
Identifiers
URN: urn:nbn:se:su:diva-175697DOI: 10.18632/aging.102274ISI: 000488275300020PubMedID: 31525731OAI: oai:DiVA.org:su-175697DiVA, id: diva2:1370171
Available from: 2019-11-14 Created: 2019-11-14 Last updated: 2019-11-14Bibliographically approved

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CiteExportLink to record
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  • apa
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