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Mitochondria orchestrate proteostatic and metabolic stress responses
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0001-8948-0685
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. University of Graz, Austria.
Number of Authors: 32019 (English)In: EMBO Reports, ISSN 1469-221X, E-ISSN 1469-3178, Vol. 20, no 10, article id e47865Article, review/survey (Refereed) Published
Abstract [en]

The eukaryotic cell is morphologically and functionally organized as an interconnected network of organelles that responds to stress and aging. Organelles communicate via dedicated signal transduction pathways and the transfer of information in form of metabolites and energy levels. Recent data suggest that the communication between organellar proteostasis systems is a cornerstone of cellular stress responses in eukaryotic cells. Here, we discuss the integration of proteostasis and energy fluxes in the regulation of cellular stress and aging. We emphasize the molecular architecture of the regulatory transcriptional pathways that both sense and control metabolism and proteostasis. A special focus is placed on mechanistic insights gained from the model organism budding yeast in signaling from mitochondria to the nucleus and how this shapes cellular fitness.

Place, publisher, year, edition, pages
2019. Vol. 20, no 10, article id e47865
Keywords [en]
mitochondria-to-nucleus signaling, organellar connectivity, protein folding, proteostasis, stress response
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-175820DOI: 10.15252/embr.201947865ISI: 000488968500012PubMedID: 31531937OAI: oai:DiVA.org:su-175820DiVA, id: diva2:1371636
Available from: 2019-11-20 Created: 2019-11-20 Last updated: 2019-11-20Bibliographically approved

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Andréasson, ClaesOtt, MartinBüttner, Sabrina
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Department of Molecular Biosciences, The Wenner-Gren InstituteDepartment of Biochemistry and Biophysics
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