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i-Pr2NMgCl center dot LiCl Enables the Synthesis of Ketones by Direct Addition of Grignard Reagents to Carboxylate Anions
Stockholm University, Faculty of Science, Department of Organic Chemistry.ORCID iD: 0000-0002-1964-9243
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.ORCID iD: 0000-0001-9199-6736
Number of Authors: 32019 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 21, no 19, p. 7908-7913Article in journal (Refereed) Published
Abstract [en]

The direct preparation of ketones from carboxylate anions is greatly limited by the required use of organolithium reagents or activated acyl sources that need to be independently prepared. Herein, a specific magnesium amide additive is used to activate and control the addition of more tolerant Grignard reagents to carboxylate anions. This strategy enables the modular synthesis of ketones from CO2 and the preparation of isotopically labeled pharmaceutical building blocks in a single operation.

Place, publisher, year, edition, pages
2019. Vol. 21, no 19, p. 7908-7913
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Chemical Sciences
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URN: urn:nbn:se:su:diva-175818DOI: 10.1021/acs.orglett.9b02899ISI: 000489200100047PubMedID: 31513423OAI: oai:DiVA.org:su-175818DiVA, id: diva2:1371677
Available from: 2019-11-20 Created: 2019-11-20 Last updated: 2019-12-04Bibliographically approved

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