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THE ROLE OF PARTICLE SPECTRA IN MODELING THE RELATIVE BIOLOGICAL EFFECTIVENESS OF PROTON RADIOTHERAPY BEAMS
Stockholm University, Faculty of Science, Department of Physics. Karolinska Institutet, Sweden; Aarhus University Hospital, Denmark.ORCID iD: 0000-0002-4160-1078
Number of Authors: 32019 (English)In: Radiation Protection Dosimetry, ISSN 0144-8420, E-ISSN 1742-3406, Vol. 183, no 1-2, p. 251-254Article in journal (Refereed) Published
Abstract [en]

Radiotherapy beams of protons or heavier ions generate secondary particles through nuclear interactions over different patient tissues. The resulting particle spectra depend on the tissue composition and on charge and energy of the primary beam ions. In proton radiotherapy, predictive radiobiological models usually apply dose-averaged linear energy transfer (LET). Microdosimetry-based models for proton or heavier ion primary beams also rely on dose-averaged quantities, the values of which depend on whether the produced secondaries are included or excluded in the calculation. In turn, this will affect the results of calculations of the relative biological effectiveness (RBE) of these beams. In this brief note, we study quantitatively the influence of the secondary radiation spectra on the averaged expectation values of LET and their impact on predictions of RBE. It is noted that for microdosimetry-based quantities and for corresponding LET-based parameters the trends are similar and that fluence-averaged quantities should be studied more closely.

Place, publisher, year, edition, pages
2019. Vol. 183, no 1-2, p. 251-254
National Category
Physical Sciences Cancer and Oncology
Identifiers
URN: urn:nbn:se:su:diva-175900DOI: 10.1093/rpd/ncy268ISI: 000489282900050PubMedID: 30566667OAI: oai:DiVA.org:su-175900DiVA, id: diva2:1372617
Conference
17th International Symposium on Microdosimetry (MICROS), Venice, Italy, November 5-10, 2017
Available from: 2019-11-25 Created: 2019-11-25 Last updated: 2019-12-09Bibliographically approved

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