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Mapping the landscape of human dopamine D2/3 receptors with [C-11]raclopride
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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Number of Authors: 142019 (English)In: Brain Structure and Function, ISSN 1863-2653, E-ISSN 1863-2661, Vol. 224, no 8, p. 2871-2882Article in journal (Refereed) Published
Abstract [en]

The dopamine D2/3 system is fundamental for sensory, motor, emotional, and cognitive aspects of behavior. Small-scale human histopathological and animal studies show high density of D2/3 dopamine receptors (D2/3DR) in striatum, but also demonstrate the existence of such receptors across cortical and limbic regions. Assessment of D2/3DR BPND in the extrastriatal regions with [C-11]raclopride has long been considered unreliable due to the relatively low density of D2/3DR outside the striatum. We describe the distribution and interregional links of D2/3DR availability measured with PET and [C-11]raclopride across the human brain in a large sample (N = 176; age range 64-68 years). Structural equation modeling revealed that D2/3DR availability can be organized according to anatomical (nigrostriatal, mesolimbic, mesocortical) and functional (limbic, associative, sensorimotor) dopamine pathways. D2/3DR availability in corticolimbic functional subdivisions showed differential associations to corresponding striatal subdivisions, extending animal and pharmacological work. Our findings provide evidence on the dimensionality and organization of [C-11]raclopride D2/3DR availability in the living human brain that conforms to known dopaminergic pathways.

Place, publisher, year, edition, pages
2019. Vol. 224, no 8, p. 2871-2882
Keywords [en]
[C-11]raclopride, Dopamine D2, 3 receptors, Inter-individual differences, Structural-equation modeling, COBRA study
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:su:diva-175745DOI: 10.1007/s00429-019-01938-1ISI: 000489147300018PubMedID: 31444615OAI: oai:DiVA.org:su-175745DiVA, id: diva2:1373267
Available from: 2019-11-26 Created: 2019-11-26 Last updated: 2019-11-26Bibliographically approved

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  • de-DE
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