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Association Between Speed of Multimorbidity Accumulation in Old Age and Life Experiences: A Cohort Study
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Università Cattolica del Sacro Cuore, Italy; Istituto Di Ricovero e Cura a Carattere Scientifico Fondazione Policlinico “A. Gemelli”, Italy.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). University of Brescia, Brescia, Italy.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Stockholm University, Faculty of Social Sciences, Stress Research Institute.ORCID iD: 0000-0002-5051-4929
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Number of Authors: 72019 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 188, no 9, p. 1627-1636Article in journal (Refereed) Published
Abstract [en]

Rapidly accumulating multiple chronic conditions (multimorbidity) during aging are associated with many adverse outcomes. We explored the association between 4 experiences throughout life-childhood socioeconomic circumstances, early-adulthood education, midlife occupational stress, and late-life social network-and the speed of chronic disease accumulation. We followed 2,589 individuals aged >= 60 years from the Swedish National Study on Aging and Care in Kungsholmen for 9 years (2001-2013). Information on life experiences was collected from detailed life-history interviews. Speed of disease accumulation was operationalized as the change in the count of chronic conditions obtained from clinical examinations, medical histories, laboratory data, drug use, and register linkages over 9 years. Linear mixed models were used to analyze the data. Speed of disease accumulation was lower in individuals with more than elementary education (for secondary, beta x time = -0.065, 95% CI: -0.126, -0.004; for university, beta x time = -0.118, 95% CI: -0.185, -0.050); for active occupations compared with high-strain jobs (beta x time = -0.078, 95% CI: -0.138, -0.017); and for richer social networks (for moderate tertile, beta x time = -0.102, 95% CI: -0.149, -0.055; for highest tertile, beta x time = -0.135, 95% CI: -0.182, -0.088). The association between childhood circumstances and speed of disease accumulation was attenuated by later-life experiences. Diverse experiences throughout life might decelerate chronic disease accumulation during aging.

Place, publisher, year, edition, pages
2019. Vol. 188, no 9, p. 1627-1636
Keywords [en]
aging, childhood socioeconomic circumstances, education, life-course, multimorbidity, occupational stress, physical resilience, social networks
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:su:diva-176766DOI: 10.1093/aje/kwz101ISI: 000492998200007PubMedID: 31274148OAI: oai:DiVA.org:su-176766DiVA, id: diva2:1377173
Available from: 2019-12-11 Created: 2019-12-11 Last updated: 2019-12-12Bibliographically approved

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