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Interaction Between Odor Identification Deficit and APOE4 Predicts 6-Year Cognitive Decline in Elderly Individuals
Stockholm University, Faculty of Social Sciences, Department of Psychology, Perception and psychophysics. New York University School of Medicine, USA; Nathan Kline Institute, USA.ORCID iD: 0000-0002-0856-0569
Stockholm University, Faculty of Social Sciences, Department of Psychology, Perception and psychophysics.
Stockholm University, Faculty of Social Sciences, Department of Psychology.
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Number of Authors: 52020 (English)In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 50, no 1, p. 3-13Article in journal (Refereed) Published
Abstract [en]

Olfactory identification impairment might indicate future cognitive decline in elderly individuals. An unresolved question is to what extent this effect is dependent on the ApoE-epsilon 4, a genotype associated with risk of Alzheimer's Disease (AD). Given the current concern about reproducibility in empirical research, we assessed this issue in a large sample (n = 1637) of older adults (60 - 96 years) from the population-based longitudinal Swedish National Study on Aging and Care in Kungsholmen (SNAC-K). A hierarchical regression analysis was carried out to determine if a low score on an odor identification test, and the presence of ApoE-epsilon 4, would predict the magnitude of a prospective 6-year change in the Mini-Mental State Examination (MMSE) after controlling for demographic, health-related, and cognitive variables. We found that overall, lower odor identification performance was predictive of cognitive decline, and, as hypothesized, we found that the effect was most pronounced among ApoE-epsilon 4 carriers. Our results from this high-powered sample suggest that in elderly carriers of the ApoE-epsilon 4 allele, odor identification impairment provides an indication of future cognitive decline, which has relevance for the prognosis of AD.

Place, publisher, year, edition, pages
2020. Vol. 50, no 1, p. 3-13
Keywords [en]
dementia, Alzheimer disease, olfactory perception, memory, aging, mild cognitive impairment
National Category
Psychology Gerontology, specialising in Medical and Health Sciences
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-176686DOI: 10.1007/s10519-019-09980-9ISI: 000498089100002PubMedID: 31760549OAI: oai:DiVA.org:su-176686DiVA, id: diva2:1377952
Available from: 2019-12-13 Created: 2019-12-13 Last updated: 2020-01-22Bibliographically approved

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Olofsson, Jonas K.Larsson, MariaWilson, Donald A.
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