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Protective Effects of Flavone from Tamarix aphylla against CCl4-Induced Liver Injury in Mice Mediated by Suppression of Oxidative Stress, Apoptosis and Angiogenesis
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. Karolinska Institutet, Sweden.
Number of Authors: 42019 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, E-ISSN 1422-0067, Vol. 20, no 20, article id 5215Article in journal (Refereed) Published
Abstract [en]

The current study aimed to investigate, for the first time, the beneficial effects of 3,5-dihydroxy-4',7-dimethoxyflavone isolated from Tamarix aphylla L. against liver injury in mice. Liver injury was induced by intraperitoneal (i.p.) injection of carbon tetrachloride (CCl4) at a dose of 0.4 mL/kg mixed in olive oil at ratio (1:4) twice a week for 6 consecutive weeks. The administration of CCl4 caused significant histopathological changes in liver tissues while the pre-treatment with the flavone at dose of 10 and 25 mg/kg ameliorated the observed liver damages. Also, it markedly reduced hepatic malondialdehyde (MDA) level as well as increased the activities of liver superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) compared with their recorded levels in CCl4 model group. Moreover, the immunohistochemical analysis demonstrated the enhancement in the protein level of B-cell lymphoma-2 (Bcl-2) while the protein levels of cysteine-aspartic acid protease-3 (caspase-3), Bcl-2-associated x protein (Bax), transforming growth factor-beta 1 (TGF-beta 1) and CD31 were suppressed following the flavone treatement. These results suggest that the flavone can inhibit liver injury induced in mice owning to its impact on the oxidation, apoptotic and angiogenesis mechanisms. Further pharmacological investigations are essential to determine the effectiveness of the flavone in human.

Place, publisher, year, edition, pages
2019. Vol. 20, no 20, article id 5215
Keywords [en]
liver injury, CCl4, Tamarix aphylla, oxidative stress, apoptosis, angiogenesis
National Category
Biological Sciences Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-177527DOI: 10.3390/ijms20205215ISI: 000498822800247PubMedID: 31640181OAI: oai:DiVA.org:su-177527DiVA, id: diva2:1383667
Available from: 2020-01-08 Created: 2020-01-08 Last updated: 2020-01-08Bibliographically approved

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El-Aarag, BishoyKhalifa, Shaden A. M.
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