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High-resolution mass spectrometry (HRMS) methods for nontarget discovery and characterization of poly- and per-fluoroalkyl substances (PFASs) in environmental and human samples
Stockholm University, Faculty of Science, Department of Environmental Science and Analytical Chemistry. Stockholm University, Science for Life Laboratory (SciLifeLab).
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Number of Authors: 52019 (English)In: TrAC. Trends in analytical chemistry, ISSN 0165-9936, E-ISSN 1879-3142, Vol. 121, article id 115420Article, review/survey (Refereed) Published
Abstract [en]

Widespread environmental contamination of legacy long-chain poly- and per-fluoroalkyl substances (PFASs) has triggered chemical regulatory action and a global transitioning to alternative PFASs. More than 5000 PFASs are now recognized on various lists, but few have been monitored despite ample evidence of unidentified organic fluorine in human and environmental samples. Nevertheless, our review of the literature indicates that nontarget analytical methods based on high-resolution mass spectrometry have been used to discover more than 750 PFASs, belonging to more than 130 diverse classes, in strategically selected environmental samples, biofluids or commercial products. Among these reports, we summarize the analytical and data-processing strategies for nontarget PFAS discovery, identify knowledge gaps and propose new areas for method development. Discovery of emerging PFASs before they are global contaminants could mitigate future contamination if strategic techniques can be developed to prioritize some of these substances for synthesis and confirmation, further monitoring, source elucidation and hazard characterization. 

Place, publisher, year, edition, pages
2019. Vol. 121, article id 115420
Keywords [en]
High-resolution mass spectrometry (HRMS), Poly-/per-fluoroalkyl substances (PFASs), Nontarget discovery, PFAS-Feature identification, Suspect screening
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-177609DOI: 10.1016/j.trac.2019.02.021ISI: 000501785000017OAI: oai:DiVA.org:su-177609DiVA, id: diva2:1384983
Available from: 2020-01-13 Created: 2020-01-13 Last updated: 2020-03-05Bibliographically approved

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D'Agostino, Lisa A.Martin, Jonathan W.
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Department of Environmental Science and Analytical ChemistryScience for Life Laboratory (SciLifeLab)
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