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Extremely Preterm Infants Have Significant Alterations in Their Conventional T Cell Compartment during the First Weeks of Life
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.ORCID iD: 0000-0001-8525-9895
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
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Number of Authors: 112020 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 204, no 1, p. 68-77Article in journal (Refereed) Published
Abstract [en]

Extremely preterm neonates are particularly susceptible to infections, likely because of severely impaired immune function. However, little is known on the composition of the T cell compartment in early life in this vulnerable population. We conducted a comprehensive phenotypic flow cytometry-based longitudinal analysis of the peripheral conventional T cell compartment of human extremely low gestational age neonates (ELGAN) with extremely low birth weight (ELBW; <1000 g) participating in a randomized placebo-controlled study of probiotic supplementation. PBMCs from ELGAN/ELBW neonates were collected at day 14, day 28, and postmenstrual week 36. Comparisons were made with full-term 14-d-old neonates. Total CD4(+) and CD8(+) T cell frequencies were markedly lower in the preterm neonates. The reduction was more pronounced among the CD8(+) population, resulting in an increased CD4/CD8 ratio. The preterm infants were also more Th2 skewed than the full-term infants. Although the frequency of regulatory T cells seemed normal in the ELGAN/ELBW preterm neonates, their expression of the homing receptors alpha 4 beta 7, CCR4, and CCR9 was altered. Notably, ELGAN/ELBW infants developing necrotizing enterocolitis before day 14 had higher expression of CCR9 in CD4(+)T cells at day 14. Chorioamnionitis clearly associated with reduced T regulatory cell frequencies and functional characteristics within the preterm group. Finally, probiotic supplementation with Lactobacillus reuteri did not impose any phenotypic changes of the conventional T cell compartment. In conclusion, notable immaturities of the T cell compartment in ELGAN/ELBW neonates may at least partially explain their increased susceptibility to severe immune-mediated morbidities.

Place, publisher, year, edition, pages
2020. Vol. 204, no 1, p. 68-77
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Immunology in the medical area
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URN: urn:nbn:se:su:diva-178655DOI: 10.4049/jimmunol.1900941ISI: 000503179200007PubMedID: 31801814OAI: oai:DiVA.org:su-178655DiVA, id: diva2:1394990
Available from: 2020-02-20 Created: 2020-02-20 Last updated: 2020-02-20Bibliographically approved

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Qazi, Khaleda RahmanBach Jensen, Georgvan der Heiden, MariekeBjörkander, SophiaHolmlund, UlrikaHaileselassie, YenenehSverremark-Ekström, Eva
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Department of Molecular Biosciences, The Wenner-Gren Institute
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