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The basic machineries for mitochondrial protein quality control
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. University of Graz, Austria.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.ORCID iD: 0000-0001-6367-3091
Number of Authors: 42020 (English)In: Mitochondrion (Amsterdam. Print), ISSN 1567-7249, E-ISSN 1872-8278, Vol. 50, p. 121-131Article in journal (Refereed) Published
Abstract [en]

Mitochondria play pivotal roles in cellular energy metabolism, the synthesis of essential biomolecules and the regulation of cell death and aging. The proper folding, unfolding and degradation of the many proteins active within mitochondria is surveyed by the mitochondrial quality control machineries. Here, we describe the principal components of the mitochondrial quality control system and recent developments in the elucidation of the molecular mechanisms maintaining a functional mitochondrial proteome.

Place, publisher, year, edition, pages
2020. Vol. 50, p. 121-131
Keywords [en]
Mitochondria, Proteostasis, Quality control, Proteases, Chaperones, Mitophagy, Aggregates
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-179697DOI: 10.1016/j.mito.2019.10.003ISI: 000508287400015PubMedID: 31669238OAI: oai:DiVA.org:su-179697DiVA, id: diva2:1412118
Available from: 2020-03-05 Created: 2020-03-05 Last updated: 2020-03-05Bibliographically approved

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Vazquez-Calvo, CarmelaBüttner, SabrinaOtt, Martin
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Department of Biochemistry and BiophysicsDepartment of Molecular Biosciences, The Wenner-Gren Institute
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