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Biophysics and the nonlinear dynamics instigated by a special hormone
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab). Comsats University Islamabad, Pakistan..
Number of Authors: 42020 (English)In: Progress in Biophysics and Molecular Biology, ISSN 0079-6107, E-ISSN 1873-1732, Vol. 150, p. 62-66Article, review/survey (Refereed) Published
Abstract [en]

Calcitonin, a potent hypocalcemic hormone, plays a vital role in inhibiting osteoclastic activities and suppressing bone removal. The physiological characteristics of calcitonin have long been discussed, along a few recommending calcitonin as a vestigial hormone. The basis for this article is to discuss the role of low and high levels of calcitonin in normal and osteoprotic bone turnover. The effect of calcitonin on the receptor activator of nuclear factor kappa-ligand and osteoclasts has been demonstrated using numerical simulations. This behavior recommends that treatment of osteoporosis via calcitonin does not provide the required upshots. For effectiveness calcitonin must be advised along with a combined therapy like aspirin which agrees with the experimental results available in the literature.

Place, publisher, year, edition, pages
2020. Vol. 150, p. 62-66
Keywords [en]
Calcitonin, Bone remodeling, Osteoporosis, Mathematical modeling, Multiscale analysis
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-179686DOI: 10.1016/j.pbiomolbio.2019.05.005ISI: 000510957500005PubMedID: 31121190OAI: oai:DiVA.org:su-179686DiVA, id: diva2:1412184
Available from: 2020-03-05 Created: 2020-03-05 Last updated: 2020-03-05Bibliographically approved

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