In recent decades, corporate social responsibility (CSR) as part of socially sustainable business organizations operations has become a common practice across developed and developing countries. The objective of this mini review is to reflect on the potential role that CSR might have on the health of stakeholders (employees and society in general). We suggest that there is an opportunity for business to become agents of change and contribute to improved population health. Therefore, public health researchers need to explore how business organizations can, through CSR impact population health currently and in years to come. This would occur through helping to address global challenges in the workplace and immediate local communities, but above all through identifying the role businesses play in contributing to sustainable development and sustainable population health/health promotion across entire societies regardless of their stage of economic development.