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Safinamide as an adjunct therapy in older patients with Parkinson's disease: a retrospective study
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Università Cattolica del Sacro Cuore, Italy.
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Number of Authors: 102020 (English)In: Aging Clinical and Experimental Research, ISSN 1594-0667, E-ISSN 1720-8319Article in journal (Refereed) Epub ahead of print
Abstract [en]

Background Safinamide, as a levodopa adjunct, is effective in reducing motor fluctuations in Parkinson's disease (PD) patients; however, scarce evidence is available regarding its use in older PD patients. Aim To evaluate the safety and tolerability of safinamide as an adjunct therapy in patients aged >= 60 years with advanced PD. Methods A retrospective study including 203 PD patients admitted to a geriatric day hospital, who were evaluated following an extensive clinical protocol. Safinamide use was categorized as never used, ongoing, and withdrawn. Potential correlations of Safinamide withdrawal were investigated in stepwise backward logistic regression models. Results A total of 44 out of 203 participants were current or former users of Safinamide. Overall, 14 (32%) patients discontinued due to treatment-emergent adverse events (TEAEs). Withdrawal was not associated with older age. Conclusions Safinamide as an adjunct therapy in patients aged >= 60 years with advanced PD was found to be safe and well-tolerated in older patients. There were no specific demographic or clinical characteristics associated with suspension.

Place, publisher, year, edition, pages
2020.
Keywords [en]
Parkinson's disease, Older patients, Safinamide
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:su:diva-179613DOI: 10.1007/s40520-020-01469-4ISI: 000509158300002PubMedID: 31981101OAI: oai:DiVA.org:su-179613DiVA, id: diva2:1415167
Available from: 2020-03-17 Created: 2020-03-17 Last updated: 2020-03-17

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