Phosphates particularly zinc phosphates is a family of conventional dental cements that was developed a century ago and has been in use until today despite the fact that a number of new resin composite cements have been introduced in the market through the years. A close inspection of thein vivoaged samples provides insides to the margins and to the micro-leakage thus would sharpen the understanding and inspire the future development of the cements and cementation interfaces between the dental restorations and the natural tooth or implant abutment. This study highlights the cementation interface and its structural change duringin vivoaging. Besides the focused studies on phosphate cements, limited investigation has also been performed on resin composite cements as references.