Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Exponential increase in mortality with age is a generic property of a simple model system of damage accumulation and death
Stockholm University, Faculty of Social Sciences, Department of Public Health Sciences.ORCID iD: 0000-0003-3827-8721
Number of Authors: 12020 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 15, no 6, article id e0233384Article in journal (Refereed) Published
Abstract [en]

The risk of dying increases exponentially with age, in humans as well as in many other species. This increase is often attributed to the accumulation of damage known to occur in many biological structures and systems. The aim of this paper is to describe a generic model of damage accumulation and death in which mortality increases exponentially with age. The damage-accumulation process is modeled by a stochastic process know as a queue, and risk of dying is a function of the accumulated damage, i.e., length of the queue. The model has four parameters and the main characteristics of the model are: (i) damage occurs at random times with a constant high rate; (ii) the damage is repaired at a limited rate, and consequently damage can accumulate; (iii) the efficiency of the repair mechanism decays linearly with age; (iv) the risk of dying is a function of the accumulated damage. Using standard results from the mathematical theory of queues it is shown that there is an exponential dependence between risk of dying and age in these models, and that this dependency holds irrespective of how the damage-accumulation process is modeled. Furthermore, the ways in which this exponential dependence is shaped by the model parameters are also independent of the details of the damage accumulation process. These generic features suggest that the model could be useful when interpreting changes in the relation between age and mortality in real data. To exemplify, historical mortality data from Sweden are interpreted in the light of the model. The decrease in mortality seen between cohorts born in 1905, compared to those born in 1885, can be accounted for by higher threshold to damage. This fits well with the many advances made in public health during the 20th century.

Place, publisher, year, edition, pages
2020. Vol. 15, no 6, article id e0233384
National Category
Public Health, Global Health and Social Medicine
Identifiers
URN: urn:nbn:se:su:diva-183670DOI: 10.1371/journal.pone.0233384ISI: 000542035200056PubMedID: 32497107OAI: oai:DiVA.org:su-183670DiVA, id: diva2:1455237
Available from: 2020-07-22 Created: 2020-07-22 Last updated: 2025-02-20Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records

Ledberg, Anders

Search in DiVA

By author/editor
Ledberg, Anders
By organisation
Department of Public Health Sciences
In the same journal
PLOS ONE
Public Health, Global Health and Social Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 51 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf