Reconstructing the occurrence of diluvial storms over centennial to millennial time-scales allows for placing the emergence of modern damaging hydrological events in a longer perspective to facilitate a better understanding of their rate of return in the absence of significant anthropogenic climatic forcing. These extremes have implications for the risk of flooding in sub-regional river basins during both colder and warmer climate states. Here, we present the first homogeneous millennium-long (800–2018 CE) time-series of diluvial storms for the Po River Basin, northern Italy, which is also the longest such time-series of monthly data for the entire Europe. The monthly reconstruction of damaging hydrological events derives from several types of historical documentary sources and reveals 387 such events, allowing the construction of storm severity indices by transforming the information into a monthly, quantitative, record. A period of reduced diluvial storms occurred in the ninth and tenth centuries, followed by a stormier period culminating in the eleventh and thirteenth centuries. More complex patterns emerge in the fourteenth to sixteenth centuries, with generally wetter and stormier conditions than during other centuries. From the seventeenth century onwards the number of damaging hydrological events decreases, with a return in recent decades to conditions similar to those prior to the thirteenth century The flood frequency tended to increase for all seasons during periods of low solar irradiance, suggesting the presence of solar-induced circulation changes resembling the negative phases of the Atlantic Multidecadal Variability as a controlling atmospheric mechanism.