This Perspective uses a social-ecological systems framework to make recommendations for global targets that capture the interdependencies of biodiversity, ecosystem services and sustainable development to inform the Convention on Biological Diversity post-2020 process and the future of the UN's Sustainable Development Goals. We are approaching a reckoning point in 2020 for global targets that better articulate the interconnections between biodiversity, ecosystem services and sustainable development. The Convention on Biological Diversity's (CBD's) post-2020 global biodiversity framework and targets will be developed as we enter the last decade to meet the Sustainable Development Goals (SDGs) and targets. Despite recent findings of unprecedented declines in biodiversity and ecosystem services and their negative impacts on SDGs, these declines remain largely unaccounted for in the SDG's upcoming 'decade of action'. We use a social-ecological systems framework to develop four recommendations for targets that capture the interdependencies between biodiversity, ecosystem services and sustainable development. These recommendations, which are primarily aimed at the CBD post-2020 process, include moving from separate social and ecological targets to social-ecological targets that: account for (1) the support system role of biodiversity and (2) ecosystem services in sustainable development. We further propose target advances that (3) capture social-ecological feedbacks reinforcing unsustainable outcomes, and (4) reveal indirect feedbacks hidden by current target systems. By making these social-ecological interdependencies explicit, it is possible to create coherent systems of global targets that account for the complex role of biodiversity and ecosystem services in sustainable development.