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Analytic solutions for stochastic hybrid models of gene regulatory networks
Stockholm University, Faculty of Science, Department of Mathematics.ORCID iD: 0000-0003-3256-6968
Number of Authors: 32021 (English)In: Journal of Mathematical Biology, ISSN 0303-6812, E-ISSN 1432-1416, Vol. 82, no 1-2, article id 9Article in journal (Refereed) Published
Abstract [en]

Discrete-state stochastic models are a popular approach to describe the inherent stochasticity of gene expression in single cells. The analysis of such models is hindered by the fact that the underlying discrete state space is extremely large. Therefore hybrid models, in which protein counts are replaced by average protein concentrations, have become a popular alternative. The evolution of the corresponding probability density functions is given by a coupled system of hyperbolic PDEs. This system has Markovian nature but its hyperbolic structure makes it difficult to apply standard functional analytical methods. We are able to prove convergence towards the stationary solution and determine such equilibrium explicitly by combining abstract methods from the theory of positive operators and elementary ideas from potential analysis.

Place, publisher, year, edition, pages
2021. Vol. 82, no 1-2, article id 9
Keywords [en]
Petri networks, Systems of PDEs, Positive C-0-semigroups, Piecewise deterministic Markov processes
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-191338DOI: 10.1007/s00285-021-01549-7ISI: 000613325500001PubMedID: 33496854OAI: oai:DiVA.org:su-191338DiVA, id: diva2:1537464
Available from: 2021-03-15 Created: 2021-03-15 Last updated: 2022-02-25Bibliographically approved

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Kurasov, PavelMugnolo, Delio

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