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Radiobiological Evaluation of Combined Gamma Knife Radiosurgery and Hyperthermia for Pediatric Neuro-Oncology
Stockholm University, Faculty of Science, Department of Physics. Karolinska Institutet, Sweden.
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Number of Authors: 62021 (English)In: Cancers, ISSN 2072-6694, Vol. 13, no 13, article id 3277Article in journal (Refereed) Published
Abstract [en]

Combining radiotherapy (RT) with hyperthermia (HT) has been proven effective in the treatment of a wide range of tumours, but the combination of externally delivered, focused heat and stereotactic radiosurgery has never been investigated. We explore the potential of such treatment enhancement via radiobiological modelling, specifically via the linear-quadratic (LQ) model adapted to thermoradiotherapy through modulating the radiosensitivity of temperature-dependent parameters. We extend this well-established model by incorporating oxygenation effects. To illustrate the methodology, we present a clinically relevant application in pediatric oncology, which is novel in two ways. First, it deals with medulloblastoma, the most common malignant brain tumour in children, a type of brain tumour not previously reported in the literature of thermoradiotherapy studies. Second, it makes use of the Gamma Knife for the radiotherapy part, thereby being the first of its kind in this context. Quantitative metrics like the biologically effective dose (BED) and the tumour control probability (TCP) are used to assess the efficacy of the combined plan.

Place, publisher, year, edition, pages
2021. Vol. 13, no 13, article id 3277
Keywords [en]
stereotactic radiotherapy, hyperthermia, CNS tumors, medulloblastoma, biological modelling, LQ model
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:su:diva-196057DOI: 10.3390/cancers13133277ISI: 000671008000001PubMedID: 34208909OAI: oai:DiVA.org:su-196057DiVA, id: diva2:1590000
Available from: 2021-09-01 Created: 2021-09-01 Last updated: 2022-02-25Bibliographically approved

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Ghaderi Aram, MortezaToma-Dasu, IulianaBlomgren, KlasDobšíček Trefná, Hana

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