The issue of regional integration has been widely analyzed and debated for a long time. Yet, there is still a limited connection between regional integration issues and geopolitical perspectives. With an analysis focused on Latin America, this study aims to map out theory and practice on this subject. In doing so, the study explores different points of view in relation to regions and geopolitics, and how these two elements are combined in the specific topic of regional integration. This article shows that, in Latin America, there are specific contributions, such as the so-called ‘geopolitics of integration’. Different variations across time and states are identified, as well as common elements such as the search for ‘autonomy’ and ‘development’ as related to issues such as ‘nationalism’ and ‘resistance’ toward imperialism.